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Cardiac Troponin I (cTnI) is a subtype of the troponin family that is commonly used as a marker for myocardial damage Cardiac troponin I is specific for cardiac tissue and is detected in the serum only if myocardial injury has occurred Because cardiac troponin I is a very sensitive and specific indicator of heart muscle (myocardium) damage serum levels can be used to help differentiate between unstable angina and myocardial infarction (heart attack) in people with chest pain or acute coronary syndrome
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A peptide MC4R agonist selectively induces cAMP production in cells expressing human MC4R (EC50 0.3 nM) over cells expressing MC1R MC3R or MC5R (EC50s 1.1 97.9 and 139.4 nM respectively) reduces food intake in rats at 3 5 and 10 nmol/animal as well as in obese db/db mice at 200 UG/animal reduces brain edema BBB permeability and hippocampal Il-1B and Tnf-a levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation
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